Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction

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Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction.

A structural model of interleukin-8 receptor type beta (IL-8R-beta) was constructed based on the structure of bacteriorhodopsin. High temperature molecular dynamics simulations were performed to search the possible conformations of loop regions in IL-8R-beta which recognize the ligand. The crystal structure of interleukin 8 (IL-8) was used as a geometric constraint of the extracellular loop reg...

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ژورنال

عنوان ژورنال: Protein Engineering Design and Selection

سال: 1997

ISSN: 1741-0126,1741-0134

DOI: 10.1093/protein/10.9.1039